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本文报道法国、瑞典五个医疗中心用支链氨基酸(BCAA)治疗肝性脑病研究的结果。采用BCAA溶液(20g/L,亮氨酸占70%,缬氨酸20%,异亮氨酸10%,加于5%糖水内)治疗,并以5%糖水为对照。方法:选酒精性、原发性胆汁性、隐原性与肝炎后性肝硬化和急性肝性脑病的患者共50例,内中2例Ⅱ级,18例Ⅲ级,30例Ⅳ_a～Ⅳ_c级,按随机双盲法分为两组,BCAA和安慰剂组各25例,后一组年龄稍轻。两组的肝性脑病程度分级、胃肠道出血的人数、输血量
This article reports the results of a study of branched-chain amino acids (BCAA) in five medical centers in France and Sweden for the treatment of hepatic encephalopathy. BCAA solution (20g / L, leucine 70%, valine 20%, isoleucine 10%, added to 5% sugar water) treatment, and 5% of the sugar as a control. Methods: A total of 50 patients with alcoholic, primary biliary, cryptogenic and posthepatitic cirrhosis and acute hepatic encephalopathy were enrolled in this study. There were 2 cases of grade Ⅱ, 18 cases of grade Ⅲ and 30 cases of Ⅳ_a ~ Ⅳ_c The patients were divided into two groups according to randomized double-blind method: 25 cases in BCAA group and placebo group, and the latter group was slightly younger. Grading of hepatic encephalopathy in both groups, number of gastrointestinal bleeding, volume of blood transfusions