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目的探讨α-干扰素应用于儿童喉乳头状瘤治疗的疗效。方法随机将湖南省儿童医院耳鼻咽喉-头颈外科2008年10月～2010年10月诊治的61例喉乳头状瘤患儿分为2组。α-干扰素治疗组31例,其中男性23例,女性8例,年龄1～6岁,平均年龄2岁;单独手术治疗组30例,其中男性20例,女性10例,年龄1～8岁,平均年龄2岁。对所有患儿做支撑喉镜或喉显微镜治疗,α-干扰素治疗组加用α-干扰素治疗。疗程结束后总结并对比分析两组患儿疗效。结果α-干扰素治疗组有效率为61%,单纯手术治疗组有效率为33%;两组比较,α-干扰素治疗组疗效明显增高,差异有统计学意义(P<0.05)。结论单纯手术治疗儿童喉乳头状瘤,疗效差,复发率高,辅以α-干扰素综合治疗,疗效明显改善,值得临床推广。
Objective To investigate the efficacy of α-interferon in children with laryngeal papilloma. Methods Totally 61 children with laryngeal papilloma diagnosed and treated in Department of Otorhinolaryngology and Head and Neck Surgery, Children’s Hospital of Hunan Province from October 2008 to October 2010 were randomly divided into two groups. Interferon α-therapy group of 31 patients, including 23 males and 8 females, aged 1 to 6 years, mean age 2 years; separate surgery group of 30 patients, 20 males and 10 females, aged 1 to 8 years , The average age of 2 years old. For all children with support laryngoscopy or laryngoscope microscopy, α-interferon treatment group plus α-interferon treatment. After the conclusion of treatment and comparative analysis of two groups of children efficacy. Results The effective rate of α-interferon treatment group was 61%, and that of the simple operation group was 33%. The efficacy of α-interferon treatment group was significantly higher than that of the control group (P <0.05). Conclusion Surgical treatment of laryngeal papilloma in children with poor efficacy and high recurrence rate, combined with α-interferon comprehensive treatment, significantly improved efficacy, worthy of clinical promotion.