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目的:探讨正常妊娠与分娩过程中血小板参数的变化及其意义。方法:观察组为正常妊娠在本院住院分娩的健康孕产妇235例,对照组选同期正常非孕妇女30例,采用肝素抗凝的静脉血。试剂为配套试剂和临检中心提供的全血质控物校准仪器。结果:在孕期两组PLT,MPV、PDW值无明显变化,仅孕晚期PLT略有减少。潜伏期及第二产程期PLT明显低于对照组(P<0.05),而MPV和PDW均显著增大(P<0.01),尤其是第二产程更为显著。结论:在分娩期,当PLT明显减少,而MPV和PDW正常或降低时提示血小板止血功能差,应及早采取措施,同时血小板参数的变化在疾病的鉴别诊断方面有一定的临床参考意义。
Objective: To investigate the changes and significance of platelet parameters during normal pregnancy and childbirth. Methods: In the observation group, 235 healthy pregnant women were hospitalized in our hospital for normal pregnancy. In the control group, 30 normal non-pregnant women were selected during the same period. The patients were given anticoagulant heparin. Reagents for reagents and clinical centers to provide full blood quality control instrument calibration. Results: There was no significant change of PLT, MPV and PDW in the two groups during pregnancy, but only a slight decrease of PLT in the third trimester of pregnancy. PLT in the incubation period and the second stage of labor was significantly lower than that in the control group (P <0.05), while the MPV and PDW were significantly increased (P <0.01), especially in the second stage of labor. CONCLUSIONS: When PLT is significantly decreased during labor and when MPV and PDW are normal or decreased, it suggests that platelet hemostasis is poor and measures should be taken as soon as possible. At the same time, changes in platelet parameters have certain clinical significance in the differential diagnosis of disease.