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目的 探讨子宫肌肉中血管紧张素 与妊娠高血压综合征 (妊高征 )发病的关系。方法 用放射免疫法测定妊高征大鼠 11只 ,正常妊娠大鼠 5只及正常未孕大鼠 4只子宫肌肉中血管紧张素 水平。结果 妊高征大鼠子宫肌肉中血管紧张素 水平 [(5 47± 89) ng/ g]较正常妊娠大鼠 [(383± 6 7) ng/ g]及正常未孕大鼠[(4 0 4± 40 ) ng/ g]均明显增高 (P<0 .0 0 5和 P<0 .0 1)。结论 子宫肌肉中血管紧张素 可能参与了妊高征的发生和发展。
Objective To investigate the relationship between angiotensin in uterine muscle and pregnancy induced hypertension (PIH). Methods The levels of angiotensin in the muscle of 11 uterus of pregnancy induced hypertension (PIH) rats, 5 normal pregnant rats and 4 normal pregnant rats were determined by radioimmunoassay. Results Compared with normal pregnant rats [(383 ± 67) ng / g] and normal pregnant rats [(40 4 ± 40 ng / g] were significantly higher (P <0.05 and P <0.01). Conclusion Angiotensin in uterine muscle may be involved in the occurrence and development of PIH.