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目的:研究复方米非司酮用于稽留流产的疗效。方法:选取经B超及妇科检查确诊为稽留流产患者共356例,随机分为复方组(复方米非司酮)和单方组(米非司酮),每组178例,分别顺序给予复方米非司酮/米非司酮和米索。用药后观察患者有无呕吐等不良反应、阴道出血、腹痛、组织物排出情况。结果:复方组中,6 h内胚胎组织自行排出率为64.61%(115/178),明显多于单方组(7.84%,14/178例),P<0.05。复方组中服用1次米索后,胚胎组织即排出的有67例,明显多于单方组(10例),P<0.05,服米索当日24 h内出血量复方组与单方组无统计学差异(48±15 ml vs 45±20 ml,P>0.05)。结论:复方米非司酮用于稽留流产的疗效优于单方米非司酮。
Objective: To study the curative effect of compound mifepristone on missed abortion. Methods: A total of 356 patients with missed abortion diagnosed by B ultrasound and gynecological examination were randomly divided into compound prescription (mifepristone) and unilateral (mifepristone), 178 patients in each group, Nespirone / mifepristone and misoprostol. Observed patients after treatment with vomiting and other adverse reactions, vaginal bleeding, abdominal pain, tissue discharge. Results: In the compound group, the rate of spontaneous discharge of embryo within 6 hours was 64.61% (115/178), significantly higher than that of unilateral group (7.84%, 14/178 cases), P <0.05. In the compound group, taking one misoprostone once a day, 67 embryos were discharged, which was significantly more than that in the unilateral group (P <0.05). There was no significant difference between the two groups (48 ± 15 ml vs 45 ± 20 ml, P> 0.05). Conclusion: The efficacy of compound mifepristone for missed abortion is better than that of unilateral mifepristone.