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目的通过测定尿液微量白蛋白(mALB)、α_1-微球蛋白(α_1-MG)、免疫球蛋白(IgG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)含量,以观察判断毒鼠强对急性中毒患者的肾功能损害及程度。方法采用免疫速率散射比浊法及人工分光光度计比色法,对38例急性毒鼠强中毒(ATI)患者微量蛋白系列的联合检测,并与15例健康者对照。结果 ATI 患者尿 mALB、α_1-MG、IgG、NAG 排泄水平较正常对照组均有明显增加(P<0.05或0.01),且相互之间呈正相关;血清毒鼠强浓度高组(174.20±99.46μg/L)与低组(52.94±20.69μg/L)尿 mALB、α_1-MG、IgG、NAG 排泄水平有显著性差异(P<0.05);且血清毒鼠强浓度与尿 mALB、α_1-MG、NAG 排泄水平呈相关。相关结论 ATI 患者急性期存在不同程度早期肾功能损害,且与血清毒鼠强毒物浓度(TET)有关;尿微量蛋白系列检测可以早期、敏感地发现肾功能损害及程度,对重度中毒者应及时防治,有效地控制抽搐。目的通过测定尿液微量白蛋白(mALB)、α_1-微球蛋白(α_1-MG)、免疫球蛋白(IgG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)含量,以观察判断毒鼠强对急性中毒患者的肾功能损害及程度。方法采用免疫速率散射比浊法及人工分光光度计比色法,对38例急性毒鼠强中毒(ATI)患者微量蛋白系列的联合检测,并与15例健康者对照。结果 ATI 患者尿 mALB、α_1-MG、IgG、NAG 排泄水平较正常对照组均有明显增加(P<0.05或0.01),且相互之间呈正相关;血清毒鼠强浓度高组(174.20±99.46μg/L)与低组(52.94±20.69μg/L)尿 mALB、α_1-MG、IgG、NAG 排泄水平有显著性差异(P<0.05);且血清毒鼠强浓度与尿 mALB、α_1-MG、NAG 排泄水平呈相关。相关结论 ATI 患者急性期存在不同程度早期肾功能损害,且与血清毒鼠强毒物浓度(TET)有关;尿微量蛋白系列检测可以早期、敏感地发现肾功能损害及程度,对重度中毒者应及时防治,有效地控制抽搐。
OBJECTIVE To determine the content of urine microalbumin, α 1 -microglobulin, immunoglobulin and N-acetylglucosaminidase (NAG) Damage and severity of tetramine in patients with acute poisoning. Methods The immunostaining nephelometry and manual spectrophotometer colorimetric method were used to detect the microalbuminuria in 38 cases of acute tetramine poisoning (ATI) patients and compared with 15 healthy controls. Results The excretion of urinary mALB, α 1-MG, IgG and NAG in patients with ATI were significantly increased (P <0.05 or 0.01), and positively correlated with each other. Serum high concentration of tetramine (174.20 ± 99.46μg (P <0.05). The levels of urinary mALB, α 1-MG, IL-6, IL-6, NAG levels were correlated. Related conclusions ATI patients have different degrees of early renal dysfunction in acute stage, which is related to the concentration of TET in serum. The detection of urine microalbumin series can detect renal damage and extent early and sensitively, Prevention, effective control of convulsions. OBJECTIVE To determine the content of urine microalbumin, α 1 -microglobulin, immunoglobulin and N-acetylglucosaminidase (NAG) Damage and severity of tetramine in patients with acute poisoning. Methods The immunostaining nephelometry and manual spectrophotometer colorimetric method were used to detect the microalbuminuria in 38 cases of acute tetramine poisoning (ATI) patients and compared with 15 healthy controls. Results The excretion of urinary mALB, α 1-MG, IgG and NAG in patients with ATI were significantly increased (P <0.05 or 0.01), and positively correlated with each other. Serum high concentration of tetramine (174.20 ± 99.46μg (P <0.05). The levels of urinary mALB, α 1-MG, IL-6, IL-6, NAG levels were correlated. Related conclusions ATI patients have different degrees of early renal dysfunction in acute stage, which is related to the concentration of TET in serum. The detection of urine microalbumin series can detect renal damage and extent early and sensitively, Prevention, effective control of convulsions.