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關於對氨水楊酸鈉的檢驗方法,蘇聯药典第八版第一補充版1952年版中所規定的是用重氮化法,但我們過去照這方法進行含量測定時,總感到困難,因為用重氮化法测定含量時,必須在對氨水楊酸钠水溶液中加塊酸,但加後很容易析出結晶,而致无法進行檢驗。經過找參考資料及數次试验。這問題才得到解决。在這方面,我體會到有下面几点: 1) 對氨水楊酸鈉雖然易溶於水,但對氨水楊酸及其鹽酸鹽却是難溶於水的。它們在水中的溶解度很低,為了使其溶解,必須加多量的水,才能在加稀鹽
As to the method of testing sodium aminosalicylate, the method of diazotization prescribed in the 1952 edition of the first edition of the eighth edition of the Soviet Union Pharmacopoeia was used, but in the past we always found it difficult to determine the content by this method, Nitriding method for the determination of content, you must add aqueous acid solution of sodium salicylic acid, but after adding very easy to precipitate crystals, and could not be tested. After looking for reference and several tests. This problem was solved. In this regard, I understand the following points: 1) although ammonia sodium salicylate soluble in water, but the ammonia salicylic acid and its hydrochloride is hardly soluble in water. Their solubility in water is very low, in order to make it dissolved, you must add a large amount of water, in addition to dilute the salt