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内皮素 (Ｅｎｄｏｔｈｅｌｉｎ ,ＥＴ)是一种由 2 1个氨基酸组成的生物活性多肽 ,是迄今发现最强大的内源性缩血管物质。头端延髓腹外侧区 (ｒＶＬＭ)是心血管活动的重要调节中枢 ,内含丰富的ＥＴ及其受体 ,ｒＶＬＭ内微量注射ＥＴ 1可诱发缺血心脏发生严重节律紊乱 ,其机理与
Endothelin (ET) is a biologically active polypeptide consisting of 21 amino acids. It is by far the most potent endogenous vasoconstrictor. Rver ventrolateral medulla (rVLM) is an important regulatory center of cardiovascular activity, rich in ET and its receptors, microinjection of ET 1 in rVLM can induce severe rhythm disorders in ischemic heart, the mechanism and