70年代动脉硬化的研究,如果说主要是HDL-C的研究并不过份,然而做为动脉硬化的危险因素HDL-C在糖尿病患者起什么作用,尚无结论,为此进行了本研究。对糖尿病患者进行临床研究,观察HDL-C的分布和每日内的波动,给予胰岛素及服降糖剂后HDL-C的变化,同时还用C~(14)标记胆固醇及H~3-标记甘氨酸进行了动物实验。在糖尿病患者,由于各种条件,多少有些差异,进行综合统计时HDL-C可呈现高值,但还不能认为它是发生动脉粥样硬化的因素,可能存在异型糖尿病的APO蛋白代谢异常,同时投入胰 The study of atherosclerosis in the 1970s, if HDL-C was not an overestimate, is not yet a conclusion as a risk factor for atherosclerosis. HDL-C plays a role in diabetic patients. To study the changes of HDL-C and intra-day fluctuation, changes of HDL-C after administration of insulin and hypoglycemic agents, as well as C ~ (14) labeled cholesterol and H ~ 3- Animal experiments were conducted. In diabetic patients, due to a variety of conditions, somewhat different, a comprehensive statistics of HDL-C can be high, but can not be considered that it is the occurrence of atherosclerosis factors, there may be abnormal diabetic APO protein metabolism, at the same time Put into the pancreas