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目的探讨尼麦角林治疗老年慢性脑血管功能不全的临床效果。方法采用随机数表法将本院神经内科2012年7月至2014年7月收治的162例老年慢性脑血管功能不全患者分为尼麦角林组和常规组,每组各81例。常规组患者采用常规治疗方法,尼麦角林组患者在常规治疗基础上加用尼麦角林。比较两组患者治疗的临床效果。结果治疗前,两组患者大脑中动脉、椎动脉的彩色多普勒超声检测指标[舒张期末流速(Vd)、收缩期峰流速(Vs)、阻力指数(RI)、搏动指数(PI)]比较差异均无显著性(P>0.05);治疗后12周,两组患者的Vd、Vs、RI、PI较组内治疗前明显好转,差异均具有显著性(P<0.05),且尼麦角林组患者的Vd、Vs、RI、PI优于常规组,差异具有显著性(P<0.05)。治疗前两组患者的简易精神状态检查量表(MMSE)评分比较差异无显著性(P>0.05);治疗后两组患者MMSE评分较治疗前均显著提高(P<0.05),且尼麦角林组患者的MMSE评分[(24.5±1.3)分]显著高于常规组[(22.9±1.5)分],差异具有显著性(P<0.05)。治疗后12周,尼麦角林组患者治疗总有效率(91.36%)高于常规组(76.54%),差异具有显著性(P<0.05)。结论尼麦角林可以改善老年慢性脑血管功能不全患者的临床症状及大脑血管血流情况,同时可以显著提高临床治疗效果。
Objective To investigate the clinical effect of nicergoline on senile chronic cerebrovascular insufficiency. Methods A total of 162 elderly patients with chronic cerebrovascular insufficiency admitted from July 2012 to July 2014 in our hospital were randomly divided into nicergoline group and control group, with 81 cases in each group. The conventional group of patients with conventional treatment, nicergoline group of patients on the basis of conventional therapy plus nicergoline. The clinical effects of two groups of patients were compared. Results Before treatment, the indexes of middle cerebral artery and vertebral artery in the two groups were compared by color Doppler ultrasonography (Vd, Vs, RI, PI) (P> 0.05). At 12 weeks after treatment, the levels of Vd, Vs, RI and PI in both groups were significantly improved before treatment, the difference was significant (P <0.05), and nicergoline Group Vd, Vs, RI, PI better than the conventional group, the difference was significant (P <0.05). There was no significant difference in MMSE score between the two groups before treatment (P> 0.05). MMSE scores of two groups were significantly higher than those before treatment (P <0.05), and nicergoline MMSE score [(24.5 ± 1.3)] in the group of patients was significantly higher than that in the conventional group [(22.9 ± 1.5)), the difference was significant (P <0.05). At 12 weeks after treatment, the total effective rate (91.36%) in the nicergoline group was higher than that in the conventional group (76.54%), with significant difference (P <0.05). Conclusion Nicergoline can improve the clinical symptoms and cerebral vascular blood flow in elderly patients with chronic cerebrovascular insufficiency, and can significantly improve the clinical therapeutic effect.