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山莨菪硷及川芎嗪对大鼠肺水肿有明显的预防作用,在肺水肿发生机理中,肺泡一毛细血管通透性增高是中心环节之一。静脉注射Evans蓝后,先注射肾上腺素造成肺水肿,用山莨菪硷或川芎嗪进行预防,应用本实验方法测定肺脏浸泡液中Evans蓝含量及肺泡支气管洗涤液中Evans蓝含量并算出通透指数。按正常组、肺水肿组、山莨菪硷组、川芎嗪组次序结果为:肺脏浸泡液中Evans蓝含量为6.3±2.6、23.6±7.5、11.3±9.3、15.8±11.0(pg/ml);支气管肺泡洗涤液中Evans蓝通透指数为0.26±0.06、19.1±3.8、1.46±0.56、1.66±1.40,肺水肿组与其他三组均有非常显著性差异,P<0.01。结果说明,肺水肿时肺—毛细血管及肺泡上皮通透性增高,山莨菪硷和川芎嗪能抑制这种增高。
Hawthorn and tetramethylpyrazine have obvious preventive effects on pulmonary edema in rats. In the mechanism of pulmonary edema, the increase of alveolar capillary permeability is one of the central aspects. After Evans Blue was injected intravenously, pulmonary edema was caused by the injection of epinephrine, and it was prevented by hawthorn or ligustrazine. The Evans blue content in the lung soaking solution and the Evans blue content in the alveolar bronchial washings were determined by this method and the permeability index was calculated. . According to the results of the normal group, pulmonary edema group, hawthorn group and ligustrazine group, the Evans blue content in the lung soaking solution was 6.3±2.6, 23.6±7.5, 11.3±9.3, and 15.8±11.0 (pg/ml); Evans blue permeation index in alveolar washings was 0.26±0.06, 19.1±3.8, 1.46±0.56, 1.66±1.40. Pulmonary edema group was significantly different from the other three groups, P<0.01. The results showed that the pulmonary-capillary and alveolar epithelial permeability increased during pulmonary edema, and hawthorn and tetramethylpyrazine inhibited this increase.