年龄相关性黄斑变性(AMD)是与年龄相关的以视网膜黄斑区病理改变导致中心视力受损为特征的致盲率较高的眼底疾病.近年来研究发现,AMD发生和发展与免疫炎症反应密切相关,但具体机制尚未阐明.核苷酸结合寡聚化结构域样受体3(NLRP3)炎症小体作为固有免疫的重要组成部分,在AMD的病理过程中发挥了重要作用.本文拟对NLRP3炎症小体在AMD中的作用进行综述,探讨其激活机制,为靶向NLRP3炎症小体的抗免疫炎症治疗AMD提供新思路.“,”Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disease characterized by the deterioration of the macula resulting in impaired visual acuity,which could probably cause irreversible vision loss.The pathogenesis of AMD is not clear yet though it has been found related to inflammation.As an important component of innate immunity,nucleotide-binding oligomerzation domain like receptors 3 (NLRP3)inflammasome may play a role in AMD.This article reviewed the progress in the studies of the role of NLRP3 inflammasome in AMD via discussing the activation mechanism of it,which may provide a novel treatment strategy of AMD by targeting NLRP3 inflammasome.