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In order to improve the safety and reliability of a launch vehicle, we present a reconfigurable guidance method based on online trajectory optimization for thrust decrease at the ascending stage of the launch vehicle in this paper. We used a multiple shooting method to convert the optimal control problem into a nonlinear programming (NLP) problem. Finally, we used the interior point method to solve the NLP problem. The simulation results show that the method can effectively adapt to thrust decreases by 5％ and 10％. This reconfigurable guidance method based on on-line planning is proposed to realize launch missions under the condition of power descent, thus verifying the feasibility of the method.