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寻找抗血吸虫病药物,除采用筛选药物方法外,根据血吸虫的代谢及生理特点设计新药也是不可忽视的一个方面。因此,尽管目前的研究对血吸虫生理、生化过程的本质尚未完全阐明,还没有找到各有效药物间的共同作用规律,但为进一步从生化途径寻找新药提供了线索。本文仅综述一些抗血吸虫病药物对曼氏血吸虫生化代谢影响的研究结果,借作研究抗血吸虫病药物时的参考。一、对糖代谢的影响曼氏血吸虫虽然寄居在宿主的含有一定氧张力的门静脉系统血管内,但它们的生存并不完全依靠于呼吸代谢,在用氰蓝染料使
Looking for anti-schistosomiasis drugs, in addition to screening drugs, according to the metabolic and physiological characteristics of schistosomiasis is also a new drug design aspect can not be ignored. Therefore, although the current research has not fully elucidated the nature of schistosomiasis physiological and biochemical processes and has not yet found the law of interaction among the effective drugs, it provides clues for further searching for new drugs from biochemical pathways. This article reviews only some of the anti-schistosomiasis drugs Schistosoma mansoni biochemical metabolism of the results of the study for the anti-schistosomiasis drug reference. First, the impact of glucose metabolism Although Schistosoma mansoni resident in the host containing certain oxygen tension of the portal vein system, but their survival does not depend entirely on the respiratory metabolism, cyanide dye in the use of