作者报道52例最近连续诊断的慢淋白血病(CLL)患者血清和尿单克隆免疫球蛋白(M 成分)系统调查的结果。年龄范围35—88岁,男性平均68岁,女性平均72岁。诊断标准基于:①外周血中淋巴细胞>15×10~9/l;②浸润骨髓的淋巴细胞≥50%;③外周血或骨髓巾非典型的淋巴细胞<10%。所有病人按 Rai和 Binet 分期系统进行分期。足够随访的38例患者分为稳定型和进展型。前者至少12个月,患者的体征和/或血液学参数保持不变,后者表现为血红蛋白浓度或血小板数降低,或淋巴结或脾脏大小增加50%,或外周血淋巴细胞6—12个月内增加1倍。采用琼脂糖电泳筛选血清和浓缩尿的单克隆免疫球蛋白异常。采 The authors reported the results of a systematic investigation of the serum and urinary monoclonal immunoglobulin (M components) in 52 recently diagnosed consecutive patients with chronic leukemia (CLL). The age range of 35-88 years old, an average of 68 years old men, women average 72 years old. Diagnostic criteria are based on: ① peripheral blood lymphocytes> 15 × 10 ~ 9 / l; ② infiltration of bone marrow lymphocytes ≥ 50%; ③ peripheral blood or bone marrow atypical lymphocytes <10%. All patients were staged by Rai and Binet staging systems. Thirty-eight patients with adequate follow-up were categorized as stable and advanced. The former is at least 12 months old. The patient’s signs and / or hematologic parameters remain the same, with the latter showing a decrease in hemoglobin concentration or platelet count or a 50% increase in lymph node or spleen size or 6-12 months in peripheral blood lymphocytes Doubled Serological and urine-concentrating monoclonal immunoglobulin anomalies were screened by agarose gel electrophoresis. Mining