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大量有关降低中心体温生理学变化科研文献的报道,低温具有麻醉和脑保护作用。最近中心体温控制作为治疗CNS疾病的方法之一已引起人们的兴趣,临床应用病例数日益增多。 作者回顾了低温应用的历史。简述了低温的有关生理学变化。中心体温降低可使全身氧耗减少、CO_2、血钾及糖代谢等相应减少、垂体活动减弱、脑电活动亦相应降低。当全身温度降至30℃时脑代谢氧耗量(CMRO_2)降至正常的50％,在15℃时CMRO_2降至正常的10％,但低温应用的严重或威胁生命的并发症是心脏的电生理不稳定性。中心体温降至27℃以下可发生室早,甚至室颤。
A large number of reports on the scientific literature to reduce physiological changes in central body temperature have hypothermia with anesthetic and brain protective effects. Recently, as one of the methods for treating CNS diseases, central temperature control has aroused people’s interest and the number of clinical applications is increasing. The author reviews the history of cryogenic applications. Briefly described the physiological changes related to low temperature. Central hypothermia can reduce systemic oxygen consumption, CO 2, potassium and glucose metabolism, etc. corresponding reduction in pituitary activity weakened, correspondingly lower EEG activity. When the whole body temperature drops to 30 ° C, the cerebral metabolic oxygen consumption (CMRO_2) drops to 50% of normal, and at 15 ° C CMRO_2 drops to 10% of normal, but the serious or life-threatening complication of hypothermia is the heart’s electricity Physiological instability. Center temperature dropped to below 27 ℃ can occur early, or even ventricular fibrillation.