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目的探讨CD15s抗原在肾移植急性排斥反应中的检测和临床意义。方法将研究对象分为移植肾功能正常组、急性排斥反应组、其他原因引起移植肾功能不全组、健康对照组,采用流式细胞仪检测外周血淋巴细胞CD15s抗原表达率。各组分别于设定日期后第1、3、7、14、28天各采集标本1次。结果 CD15s抗原在移植肾功能正常组呈先降后升变化,但与其他原因引起肾功能不全组无显著差异;CD15s抗原表达率在急性排斥反应时明显增加(P<0.01),抗排斥治疗后逐渐下降。结论 CD15s抗原作为一项肾移植术后急性排斥反应的检测指标,能够准确反映患者的免疫功能状态。
Objective To investigate the detection and clinical significance of CD15s antigen in acute rejection of renal allograft. Methods The subjects were divided into normal renal transplantation group and acute rejection group. Other causes of renal allograft dysfunction and healthy control group were used to detect the expression of CD15s antigen in peripheral blood lymphocytes by flow cytometry. Each group were collected on the 1st, 3rd, 7th, 14th and 28th day after the set date. Results The expression of CD15s antigen in the normal renal graft group changed first and then decreased, but no significant difference was found between the CD15s antigen group and the renal insufficiency group. The expression of CD15s antigen in acute rejection group was significantly increased (P <0.01) decreasing gradually. Conclusion CD15s antigen as an indicator of acute rejection after renal transplantation can accurately reflect the patient’s immune function status.