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目的探讨不同血糖水平患者血液流变学各项指标变化的临床意义。方法通过检测30例确诊糖尿病患者、30例确诊糖耐量异常患者与30名正常人的血液流变学6项指标,分析其特点及临床意义。结果糖尿病患者的全血高切黏度、全血低切黏度、血浆黏度、血纤维蛋白原4项指标与正常对照组比较,有明显增高(P<0.05)。而红细胞压积及红细胞沉降率与正常对照组比较无明显变化(P>0.05)。结论糖尿病患者多伴有血液流变学的改变,且这种改变从糖耐量异常时即已发生,所以早期进行血液流变学检测,对预防糖尿病和控制其并发症的发生有重要意义。
Objective To investigate the clinical significance of various indexes of hemorheology in patients with different blood glucose levels. Methods Six indexes of hemorheology in 30 patients diagnosed with diabetes mellitus, 30 patients with impaired glucose tolerance and 30 normal persons were detected and their characteristics and clinical significance were analyzed. Results The indexes of whole blood hyperviscosity, whole blood low shear viscosity, plasma viscosity and fibrinogen in diabetic patients were significantly higher than those in normal controls (P <0.05). The hematocrit and erythrocyte sedimentation rate compared with the normal control group had no significant change (P> 0.05). Conclusions Patients with diabetes mellitus often have hemorheological changes, and this change occurs from the time of impaired glucose tolerance. Therefore, the early detection of hemorheology is of great significance in the prevention of diabetes and the control of complications.