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人们认识到维生素A对动物的致畸已有30余年。Cohlan曾用每日7.5万IU以上剂量的维生素A在Wistar鼠中诱发出种种畸形,如露脑、唇裂、腭裂等,这相当一个成人每日使用2500万IU以上。Giroud等证实,250IU/d的剂量就能在鼠中诱发畸形,相当于一个成人每日使用25万IU。Seller等对卷尾鼠作过观察,在妊娠第八天给母鼠按每公斤体重1.5万IU以上的维生素A会增加畸胎的可能性,而在妊娠第9天给予则无影响。迄今为止,关于维生素A对人的致畸胎作用的信息不多,曾有婴儿泌尿生殖道畸形的报导两例,其母在怀孕期每天服用维生素A 2.5～5万IU;
People have realized that vitamin A has been teratogenic to animals for more than 30 years. Cohlan used more than 75,000 doses of vitamin A daily to induce various deformities in the Wistar rat, such as the brain, cleft lip and cleft palate, which is equivalent to using more than 25 million IU daily for one adult. Giroud et al. Demonstrated that a dose of 250 IU / d can induce deformities in the rat, equivalent to 250,000 IU daily for one adult. The Seller et al. Observed the entomocervical rat. At day eight of gestation, vitamin A administered at a dose of more than 15,000 IU per kg of body weight increases the possibility of teratogenicity, while giving no effect on the 9th day of gestation. So far, little information is available on the role of vitamin A in teratogenic effects in humans. Two cases of genitourinary tract deformity have been reported in infants. The mother took 2.5 to 50,000 IU of vitamin A daily during pregnancy.