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单核细胞(MC)受到过度刺激和/或MC对成纤维细胞(Fb)生长及生物合成的抑制作用不够,可能是许多纤维化疾病的重要发病机理。由于结节病在发生肺纤维化阶段之前就存在MC的炎症过程,作者推测MC对Fb生长的抑制作用减弱,可能是结节病组织纤维化的发病机理。为了证实这一假设,作者分别对从未经刺激和已经植物血疑素(PHA)刺激的正常志愿者以及结节病和其他肺部疾病患者的血液与肺MC上清液,观察其对正常肺组织的Fb生长的影响并进行比较。研究方法:结节病患者27俐,其中男性9例,女性18例,胸部X线表现Ⅰ、Ⅱ期者各12例,Ⅲ期者3
The over-stimulation of monocytes (MCs) and / or the insufficient inhibitory effect of MCs on the growth and biosynthesis of fibroblasts (Fb) may be an important pathogenesis of many fibrotic diseases. Because sarcoidosis exists in the inflammatory process of MC before the onset of pulmonary fibrosis, we hypothesize that the suppressive effect of MC on Fb growth may be weakened, which may be the pathogenesis of sarcoidosis. To confirm this hypothesis, the authors observed the effects of normal and non-stimulated PHA-stimulated normal volunteers and patients with sarcoidosis and other lung diseases, respectively, on blood and lung MC supernatants to normal The effects of Fb growth in lung tissue were compared and compared. Research Methods: 27 patients with sarcoidosis, including 9 males and 18 females, chest X-ray showed Ⅰ, Ⅱ, 12 cases of each, Ⅲ, 3