The kinetics of Athabasca bitumen derived heavy gas oil over NiMo/Al2O3 catalysts were studied in a JQ-II high-pressure microscale hydrotreator unit under different operation conditions, including temperature, pressure, H/O ratio and LHSV. The multi-parameter models of hydrodesulfurization and hydrodenitrogenation were proposed. The model parameters verify that the HDS and HDN reactions follow 1.5-order and 1.6-order kinetic rules, respectively. The kinetic activation energies of HDN and HDS over Com, Hom1 and Hom2 show that homemade catalysts exhibit higher activities in HDN than commercial catalyst. Using the multi-parameter kinetic model to predict the contents of sulfur and nitrogen in products is in good agreement with the experimental data.