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目的：研究慢性肾功能衰竭（肾衰）患者氧自由基代谢和免疫功能状态的变化以及两者的关系。方法：测定８０例慢性肾衰患者和３０例正常人血清脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）、可溶性白细胞介素２受体（ＳＩＬ２Ｒ）和外周血Ｔ淋巴细胞亚群的水平并进行比较。结果：慢性肾衰患者血清ＬＰＯ、ＳＯＤ和ＳＩＬ２Ｒ水平较正常人明显升高（Ｐ均＜０．０１），外周血Ｔ淋巴细胞亚群ＣＤ＋３、ＣＤ＋４、ＣＤ＋８细胞及ＣＤ＋４／ＣＤ＋８比值则显著降低（Ｐ＜０．０５或Ｐ＜０．０１）。血清ＳＯＤ及ＳＩＬ２Ｒ水平与血肌酐（ＳＣｒ）呈显著正相关，与肾小球滤过率（ＧＦＲ）呈显著负相关；血清总ＳＯＤ、ＣｕＺｎＳＯＤ活性与ＳＩＬ２Ｒ水平呈显著正相关。结论：慢性肾衰患者存在氧自由基的蓄积，脂质过氧化反应的病理性亢进和超氧化物歧化酶代偿性增高及免疫功能异常的病理改变；血清ＳＯＤ、ＳＩＬ２Ｒ水平可作为肾功能损害的客观指标。
Objective: To investigate the changes of oxygen free radical metabolism and immune function in patients with chronic renal failure (renal failure) and their relationship. Methods: The levels of serum lipid peroxides (LPO), superoxide dismutase (SOD), soluble interleukin 2 receptor (SIL2R) and peripheral blood T lymphocyte subsets in 80 patients with chronic renal failure and 30 normal individuals were determined. Group level and compare. Results: Serum levels of LPO, SOD and SIL2R in patients with chronic renal failure were significantly higher than those in normal controls (all P <0.01), while the ratios of CD + 3, CD 4, CD 8 and CD 4 / CD 8 in T lymphocyte subsets were significantly decreased P <0.05 or P <0.01). Serum levels of SOD and SIL2R were positively correlated with serum creatinine (SCr) and negatively correlated with glomerular filtration rate (GFR). Serum total SOD and CuZnSOD activity were positively correlated with SIL2R levels. Conclusion: The accumulation of oxygen free radicals, the pathological hyperlipidemia of lipid peroxidation and the compensatory increase of superoxide dismutase and pathological changes of immune dysfunction exist in patients with chronic renal failure. Serum levels of SOD and SIL2R may be used as indicators of renal dysfunction Objective indicators.