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环磷酰胺(CY)及异环磷酰胺是治疗造血系统恶性肿瘤的常用化疗药物。最常见的副作用是出血性膀胱炎。我们以巯乙磺酸钠(Mesna)(Uromitex-an,Asta-Werke产品)作为预防出血性膀胱炎措施之一,对1991年1月至1992年10月间住院治疗的非何杰金淋巴瘤(NHL)130例次的治疗进行了观察,现报告如下: 36例NHL患者,男25例,女11例,年龄13～74岁。均经淋巴结活检或穿剌细胞学诊断为NHL。均接受CY或异环磷酰胺在内的联合化疗。CY的总剂量1200～2000mg/次,异环磷酰胺2000mg/次。
Cyclophosphamide (CY) and ifosfamide are common chemotherapeutic agents used to treat hematopoietic malignancies. The most common side effect is hemorrhagic cystitis. We used Mesna (Uromitex-an, Asta-Werke product) as one of the measures to prevent hemorrhagic cystitis and treated non-Hodgkin’s lymphoma, hospitalized from January 1991 to October 1992 (NHL) 130 cases of treatment were observed, the report is as follows: 36 patients with NHL, 25 males and 11 females, aged 13 to 74 years. Lymph node biopsy or puncture cytology were diagnosed as NHL. All received CY or ifosfamide combination chemotherapy. CY total dose of 1200 ~ 2000mg / ifosfamide 2000mg / times.