论文部分内容阅读
目的研究肾血流动力学与肝病病程的关系,证实肾血流阻力指数是否可作为预测失代偿期肝硬化患者肝肾综合征的指标。方法选择2004年4月至2006年7月北京大学第一医院感染疾病科超声室检查并确诊的失代偿期肝硬化患者共41例,检测血肌酐、血胆红素、凝血酶原国际标准化比值(INR),计算终末期肝病评分模型(MELD),并行多普勒超声检测计算肾血流阻力指数(RI),分析RI与临床生化检查结果和MELD积分的相关性。结果RI与患者年龄、血红蛋白量和收缩压无相关性。RI与MELD积分的相关系数r=0.502,P<0.05,二者呈明显的正相关关系。结论彩色多普勒超声检测可较准确地测定肝硬化患者的肾血流动力学的变化,可辅助临床早期预测失代偿期肝硬化患者是否出现肝肾综合征。
Objective To study the relationship between renal hemodynamics and the course of liver disease, and to confirm whether renal blood flow resistance index can be used as an index to predict hepatorenal syndrome in patients with decompensated cirrhosis. Methods A total of 41 patients with decompensated cirrhosis who were diagnosed and diagnosed in Department of Infectious Diseases, Peking University First Hospital from April 2004 to July 2006 were enrolled. Serum creatinine, serum bilirubin and prothrombin Ratio (INR), calculate end-stage liver disease score model (MELD), parallel Doppler ultrasound to calculate renal blood flow resistance index (RI), and analyze the correlation between RI and clinical biochemical test results and MELD score. Results There was no correlation between RI and patient’s age, hemoglobin level and systolic blood pressure. The correlation coefficient between RI and MELD score was 0.502, P <0.05, which showed a significant positive correlation. Conclusion Color Doppler ultrasound can be more accurate determination of changes in renal hemodynamics in patients with cirrhosis can be an early clinical prediction of liver cirrhosis in patients with decompensated liver and kidney syndrome.