糖尿病肾病(DN)是糖尿病严重的微血管并发症之一,也是导致糖尿病患者死亡的重要原因。DN的发病机制目前还未明确,传统观念认为,在遗传因素与长期高血糖等环境因素相互作用下,肾小球血流量、滤过率及压力增加,肾组织缺血、缺氧,蛋白非酶糖基化、多元醇途径活化及氧化应激。这些异常 Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes and is also an important cause of death in diabetic patients. The pathogenesis of DN is not yet clear, the traditional view that the interaction of genetic factors and long-term high blood sugar and other environmental factors, glomerular blood flow, filtration rate and increased pressure, renal ischemia, hypoxia, protein Enzyme glycosylation, polyol pathway activation and oxidative stress. These exceptions