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为探讨网膜、肠系膜间质瘤临床病理、免疫组织化学特征 ,对 8例网膜、肠系膜间质瘤作了临床病理形态学观察和免疫组织化学分析 ,而且所有肿瘤均获得随访资料。结果表明 ,肿瘤为单发结节 ,体积大 ,组织学上主要由具有嗜酸性胞浆及核两端存在细胞浆空泡的梭形细胞构成 ,部分肿瘤可见上皮样细胞等平滑肌分化证据。免疫表型特征为 :8例 (10 0 % )肿瘤C kit均为阳性 ,7例 (87 5 % )CD34阳性 ,6例 (75 % )SMA呈局灶性或散在阳性。 2例恶性间质瘤P5 3、PCNA表达阳性 ,良性病例中 1例PCNA低水平表达。结果提示 ,网膜、肠系膜间质瘤有其独立临床病理特征 ,免疫组化C kit、CD34标记物对网膜、肠系膜间质瘤具有重要意义。
To explore the clinicopathological and immunohistochemical features of omentum and mesentery stromal tumor, 8 cases of omental and mesenchymal stromal tumors were observed by clinicopathological and immunohistochemical analysis, and all the tumors were followed up. The results showed that the tumors were solitary nodules and were bulky. Histologically, the tumors mainly consisted of spindle cells with eosinophilic cytoplasm and vacuolar vacuoles at both ends of the nucleus. Some tumors showed evidence of smooth muscle differentiation such as epithelioid cells. The immunophenotype was characterized by positive C kit in 8 cases (100%), CD34 positive in 7 cases (87.5%) and focal or scattered positive in 6 cases (75%). Two cases of malignant stromal tumors P5 3, PCNA expression was positive, one case of benign cases of low expression of PCNA. The results suggest that omentum, mesenchymal stromal tumors have their own independent clinicopathological features, immunohistochemical C kit, CD34 markers on the omentum, mesentery stromal tumors is of great significance.