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目的 探讨血管内皮生长因子 (VEGF)对卵巢恶性肿瘤的诊断和病情监测作用。方法 收集卵巢肿瘤 6 5例为研究对象 ,采用酶联免疫法动态检测血清VEGF水平 ,内胚窦瘤病例同时放免测定血清甲胎蛋白(AFP)水平。结果 ①卵巢恶性肿瘤术前血清VEGF水平明显高于卵巢良性肿瘤和健康妇女 ,晚期病例明显高于早期病例 ,均有极显著差异。②血清VEGF与AFP水平均随卵巢恶性肿瘤病情控制而变化 ,且两者呈高度正相关。动态监测血清VEGF水平诊断卵巢恶性肿瘤及其分期和预后的准确性均在 80 %以上。结论 血清VEGF水平与卵巢恶性肿瘤的生长、转移和预后有密切关系 ,具有肿瘤标志物特性 ,可作为卵巢恶性肿瘤的诊断和病情监测指标
Objective To investigate the role of vascular endothelial growth factor (VEGF) in the diagnosis and disease surveillance of ovarian cancer. Methods Totally 65 cases of ovarian tumors were collected for the study. Serum VEGF levels were detected by enzyme-linked immunosorbent assay (ELISA), and the level of serum AFP was measured by radioimmunoassay simultaneously. Results ① Preoperative serum VEGF levels in ovarian cancer were significantly higher than those in benign ovarian tumors and healthy women. The late stage cases were significantly higher than the early stage cases, with significant differences. ② Serum levels of VEGF and AFP both changed with the control of ovarian cancer, and the two were highly correlated. Dynamic monitoring of serum VEGF levels in the diagnosis of ovarian cancer and staging and prognosis of the accuracy of more than 80%. Conclusion The serum level of VEGF is closely related to the growth, metastasis and prognosis of ovarian cancer, which has the characteristics of tumor markers and can be used as a diagnostic and prognostic indicator of ovarian cancer