异菸肼(INH)是临床常用的有效抗结核药物,如果一次大量服用可发生严重毒性反应甚至致死。据国内外报道1.5克一次口服在成人可产生毒性反应,6—10克急性口服能致严重中毒和死亡。一位曾有癫痫病史的患者一次服用3mg/kg的剂量发生致死性癫痫状态。我科1987年以来,收治急性重度INH中4毒例,一次吞服药量为8.0 Isoniazid (INH) is a commonly used and effective anti-TB drug in clinical practice. Serious toxic reactions and even death may occur if taken in large quantities. According to domestic and international reports of 1.5 grams of oral once in adults can produce toxic reactions, 6-10 grams of acute oral can cause severe poisoning and death. One patient who had a history of epilepsy developed a lethal, epileptic condition at a dose of 3 mg / kg. Since 1987, our department has admitted 4 cases of acute severe INH, with a dosage of 8.0