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用654-2防治油酸引起的狗呼吸窘迫综合征;分析观察了支气管肺泡灌洗液中吞噬细胞的数量、功能及超微结构等改变。结果发现,654-2能减轻油酸对肺泡巨噬细胞(AM)的损伤,保护AM的吞噬功能,减少因白细胞扣押于肺内而导致的肺损伤。
Prevention and treatment of oleic acid-induced dog respiratory distress syndrome with 654-2; analysis of changes in the number, function and ultrastructure of phagocytic cells in bronchoalveolar lavage fluid. The results showed that 654-2 could reduce the damage of oleic acid to alveolar macrophages (AM), protect the phagocytosis of AM, and reduce the lung injury caused by leukocyte sequestration in lung.