据Chivukula RR 2014年5月27日[Cell,2014,157(5):1104-1116.]报道,美国德州大学癌症研究人员发现,在抑制结肠癌中的一个重要microRNA簇,也在肠道伤口愈合中发挥关键作用。研究结果首先在小鼠中获得,其后在人类细胞中得到再现。研究确定了microRNA在调节肠道伤口愈合中的一种新作用。这一发现对疾病如溃疡性结肠炎和克罗恩病有重要影响,并可能与其他组织中创面愈合机制相关。溃疡性结肠炎和克罗恩病是两种最常见的炎性肠疾病,源于一个异常的免疫反应。结肠慢性损伤被认为是结直肠癌的危险因素,了解所涉及的细胞通路,最终可能导致潜在的治疗方法。研究人员研究这些微小的“监管机构”(microRNA)如何正常工作,以及 According to Chivukula RR, May 27, 2014 [Cell, 2014, 157 (5): 1104-1116] reported that cancer researchers at the University of Texas in the United States found that an important microRNA cluster in the inhibition of colon cancer was also found in intestinal wounds Healing plays a key role. The results were first obtained in mice and later in human cells. The study identified a new role for microRNAs in regulating intestinal wound healing. This finding has a significant impact on diseases such as ulcerative colitis and Crohn’s disease and may be related to wound healing mechanisms in other tissues. Ulcerative colitis and Crohn’s disease are the two most common inflammatory bowel diseases that result from an abnormal immune response. Chronic colon injury is considered a risk factor for colorectal cancer, and understanding the cellular pathways involved may ultimately lead to potential treatments. Researchers study how these tiny “microRNAs” work properly, and