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目的:探讨TGF-β1及COX-2在分化型甲状腺癌形成中的表达及意义。方法:用免疫组化法分别检测分化型甲状腺癌及癌旁组织中TGF-β1及COX-2表达及分布。结果:癌组织和癌旁组织TGF-β1阳性细胞百分数均值分别为(67.20±11.08)%和(15.32±8.03)%,两组间差异有统计学意义(P<0.05);癌组织和癌旁组织病例阳性率分别为83.75%,0%,两组间差异有统计学意义(P<0.01);癌组织和癌旁组织COX-2阳性细胞百分数均值分别为(84.17±10.80)%和(11.53±6.70)%,两组间差异有统计学意义(P<0.05);癌组织和癌旁组织病例阳性率分别为70%,0%,两组间差异有统计学意义(P<0.01);染色阳性细胞主要表达于甲状腺癌细胞。结论:TGF-β1及COX-2表达增高与分化型甲状腺癌形成有关,TGF-β1可能通过调节COX-2表达,共同参与分化型甲状腺癌的形成。
Objective: To investigate the expression of TGF-β1 and COX-2 in differentiated thyroid carcinoma and its significance. Methods: The expression and distribution of TGF-β1 and COX-2 in differentiated thyroid carcinoma and paracancerous tissues were detected by immunohistochemistry. Results: The mean percentages of TGF-β1 positive cells in cancer tissues and adjacent non-cancerous tissues were (67.20 ± 11.08)% and (15.32 ± 8.03)%, respectively, with significant difference between the two groups (P <0.05) The positive rates of COX-2 positive cells were 83.75% and 0% respectively in the two groups (P <0.01). The average percentage of COX-2 positive cells in cancer tissues and adjacent tissues were (84.17 ± 10.80)% and ± 6.70)% respectively. There was a significant difference between the two groups (P <0.05). The positive rates of cancer tissues and paracancer tissues were 70% and 0%, respectively. There was significant difference between the two groups (P <0.01). Dyed positive cells are mainly expressed in thyroid cancer cells. Conclusion: The increased expression of TGF-β1 and COX-2 is associated with the formation of differentiated thyroid carcinoma. TGF-β1 may participate in the formation of differentiated thyroid carcinoma by regulating the expression of COX-2.