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目的探讨心房纤颤合并冠心病的患者在心室率控制过程中N末端B型利钠肽原(NTproBNP)水平变化的趋势。方法 68例慢性心房纤颤患者按冠脉造影结果分为研究组(合并冠心病,35例)和对照组(未合并冠心病,33例),两组均接受严格的心室率控制治疗,观察治疗前后NT-proBNP水平的变化。结果研究组在严格控制心室率后,NT-proBNP水平显著下降,差异有统计学意义(P<0.05),对照组在严格控制心室率后NT-proBNP水平降幅不明显,差异无统计学意义(P>0.05)。结论心房纤颤合并冠心病患者,经严格控制心室率后,NT-proBNP水平降低,可能有利于心功能改善、减少临床事件的发生。
Objective To investigate the change of N-terminal NT-proBNP in patients with atrial fibrillation and coronary heart disease during ventricular rate control. Methods 68 patients with chronic atrial fibrillation were divided into study group (35 cases with coronary heart disease) and control group (without coronary heart disease, 33 cases) according to coronary angiography results. Both groups were treated with strict ventricular rate control. Changes of NT-proBNP levels before and after treatment. Results The NT-proBNP level in the study group decreased significantly after the ventricular rate was strictly controlled (P <0.05). The NT-proBNP level in the control group was not significantly decreased after the ventricular rate was strictly controlled (P <0.05), and the difference was not statistically significant P> 0.05). Conclusions In patients with atrial fibrillation and coronary heart disease, the NT-proBNP level decreased after strict control of ventricular rate, which may be beneficial to the improvement of cardiac function and reduce the occurrence of clinical events.