Low power CMOS preamplifier for neural recording applications

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A fully-differential bandpass CMOS(complementary metal oxide semiconductor) preamplifier for extracellular neural recording is presented.The capacitive-coupled and capacitive-feedback topology is adopted.The preamplifier has a midband gain of 20.4 dB and a DC gain of 0.The -3 dB upper cut-off frequency of the preamplifier is 6.7 kHz.The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands. It has an input-referred noise of 8.2μVrms integrated from 0.15 Hz to 6.7 kHz for recording the local field potentials and the mixed neural spikes with a power dissipation of 23.1μW from a 3.3 V supply.A bandgap reference circuitry is also designed for providing the biasing voltage and current.The 0.22 mm~2 prototype chip,including the preamplifier and its biasing circuitry,is fabricated in the 0.35-μm N-well CMOS 2P4M process. A fully-differential bandpass CMOS (complementary metal oxide semiconductor) preamplifier for extracellular neural recording is presented. The capacitive-coupled and capacitive-feedback topology is adopted. The pre-amplifier has a midband gain of 20.4 dB and a DC gain of 0. The - 3 dB upper cut-off frequency of the preamplifier is 6.7 kHz. The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands. It has an input-referred noise of 8.2 μVrms integrated from 0.15 Hz to 6.7 kHz for recording the local field potentials and the mixed neural spikes with a power dissipation of 23.1 μW from a 3.3 V supply. A bandgap reference circuitry is also designed for providing the biasing voltage and current. 0.22 mm ~ 2 prototype chip, including the preamplifier and its biasing circuitry, is fabricated in the 0.35-μm N-well CMOS 2P4M process.
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