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[目的]探讨西酞普兰对围化疗期癌症抑郁患者的临床疗效.[方法]选择105例癌症伴抑郁患者,随机分为治疗组和对照组,对照组单纯化疗,治疗组在此基础上应用西酞普兰进行抗抑郁治疗,比较两组疗效和不良反应.[结果]治疗组化疗有效率为56.6%,对照组为30.8%,治疗组控制率为94.2%,对照组为63.5%,两组疗效差异显著(P﹤0.05),治疗组有效率和控制率均高于对照组;采用副反应量表(TESS)评分评定化疗的不良反应,治疗组各期评分均低于对照组(P﹤0.05),说明治疗组不良反应较对照组为轻。[结论]西酞普兰联合化疗能提高化疗的疗效,减轻化疗的毒副反应。该方法值得临床进一步推广应用。
[Objective] To investigate the clinical efficacy of citalopram in patients with cancer depression during perioperative chemotherapy. [Methods] 105 patients with cancer accompanied by depression were randomly divided into treatment group and control group. The control group received chemotherapy alone. The treatment group was used on the basis of this Citalopram was used for antidepressant treatment, and the efficacy and adverse reactions of the two groups were compared. [Results] The effective rate of chemotherapy was 56.6% in the treatment group, 30.8% in the control group, 94.2% in the treatment group and 63.5% in the control group (P <0.05). The effective rate and control rate of the treatment group were higher than those of the control group. Adverse reaction of chemotherapy was evaluated by the TESS score, and the score of the treatment group was lower than that of the control group (P < 0.05), indicating that the treatment group adverse reactions than the control group was light. [Conclusion] Citalopram combined with chemotherapy can improve the curative effect of chemotherapy and reduce the side effects of chemotherapy. The method is worth further clinical application.