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应用单克隆抗体免疫组织化学技术对８０例甲状腺粗针穿刺标本进行原位研究。结果发现甲状腺上皮ＤＲ抗原异常表达与活化淋巴细胞、肿瘤坏死因子、白细胞介素２和γ－干扰素呈正相关。提示细胞因子对甲状腺ＤＲ抗原的诱导、自身免疫损伤具有重要作用。
In situ hybridization was performed on 80 specimens of thyroid needle with monoclonal antibody immunohistochemistry. The results showed that the abnormal expression of thyroid epithelial DR antigen was positively correlated with activated lymphocytes, tumor necrosis factor, interleukin 2 and interferon-γ. Tip cytokines on the induction of thyroid DR antigen, autoimmune injury has an important role.