肺动脉高压是临床众多心肺血管疾病发生发展中重要的病理生理环节。肺动脉高压的发生机制至今尚不清楚,血管活性物质失衡是其重要机制之一。肾上腺髓质素是一种在人体中具有保护作用的活性多肽。动物试验及临床研究均表明,肾上腺髓质素可通过舒张肺血管以及抑制内皮损伤和凋亡、抑制平滑肌和成纤维细胞增生等有效缓解肺动脉高压形成。文章将重点叙述肾上腺髓质素在肺动脉高压发生和发展中的作用。 Pulmonary hypertension is an important pathophysiological link in the development of many cardiopulmonary vascular diseases. The pathogenesis of pulmonary hypertension is still unclear. The imbalance of vasoactive substances is one of the important mechanisms. Adrenomedullin is an active polypeptide that has a protective effect in the human body. Animal experiments and clinical studies have shown that adrenomedullin can effectively alleviate the formation of pulmonary hypertension by relaxing the pulmonary vascular and inhibiting endothelial injury and apoptosis, inhibiting smooth muscle and fibroblast proliferation. The article will highlight the role of adrenomedullin in the development and progression of pulmonary hypertension.