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目的比较在发病后早期和晚期入院的手足口病(hand,foot and mouth disease,HFMD)儿童一般临床资料和血清细胞因子水平,分析其对临床诊疗的指导意义。方法对北京佑安医院院2011-05/2013-06月收治的284例手足口病患儿临床资料进行回顾性分析,根据入院时发病天数,将284例患儿分为早期组(入院时发病≤3天)158例和晚期组(入院时发病>3天)126例,比较两组的临床特点,同时采用Luminex液相芯片方法检测2组患儿血清中的5种细胞因子,包括白细胞介素(interleukin-2、interleukin-6、interleukin-10,IL-2、IL-6、IL-10),肿瘤坏死因子(tumor necrosis factor alpha,TNF-α)和干扰素(interferon gamma,IFN-γ)。结果两组患者入院时的性别、月龄、住院天数、死亡例数、血白细胞计数和随机血糖水平均无统计学差异,两组患者IL-2、IL-6、IL-10、TNF-α和IFN-γ也无统计学差异(P>0.05)。结论即使因具有高危因素而住院的患者,发病早期入院和晚期入院的主要临床资料和细胞因子水平均无明显区别,无法采用已知高危因素在入院时识别HFMD重症病例。
Objective To compare the clinical data and serum cytokines levels of children with HFMD who were hospitalized early and late after onset, and to analyze their clinical significance. Methods The clinical data of 284 children with hand-foot-mouth disease admitted to Beijing You’an Hospital from 2011-05 to 2013-06 were retrospectively analyzed. According to the number of days of admission, 284 children were divided into the early group ≤3 days) 158 cases and advanced group (onset of admission> 3 days) 126 cases, the clinical features of the two groups were compared.Meanwhile, 5 kinds of cytokines in serum of 2 groups were detected by Luminex liquid chip method, including leukocyte Interleukin-2, interleukin-10, IL-2, IL-6 and IL-10, tumor necrosis factor alpha and interferon gamma ). Results There were no significant differences in gender, age, length of hospital stay, number of deaths, white blood cell count and random blood sugar levels between the two groups. The levels of IL-2, IL-6, IL-10 and TNF- And IFN-γ nor statistical difference (P> 0.05). Conclusion Even in patients hospitalized with high risk factors, there are no significant differences in the main clinical data and cytokine levels between the early onset of admission and late admission, and the high risk factors of HFMD can not be identified with known risk factors.