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目的分析老年急性脑出血患者血清炎性因子水平变化及其临床意义。方法选取2013年3月—2016年3月东莞市第八人民医院收治的老年急性脑出血患者60例作为观察组,另选取同期体检健康者60例作为对照组。比较两组受试者及不同严重程度、预后急性脑出血患者血清炎性因子水平。结果观察组患者血清白介素1(IL-1)、白介素6(IL-6)、白介素10(IL-10)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)水平高于对照组(P<0.05)。重度急性脑出血患者血清IL-1、IL-6、IL-10、hs-CRP、TNF-α水平高于轻度、中度急性脑出血患者,中度急性脑出血患者血清IL-1、IL-6、IL-10、hs-CRP、TNF-α水平高于轻度急性脑出血患者(P<0.05)。死亡患者血清IL-1、IL-6、IL-10、hs-CRP、TNF-α水平高于存活患者(P<0.05)。结论老年急性脑出血患者血清炎性因子水平升高,且其与患者病情严重程度及预后有关。
Objective To analyze the changes of serum inflammatory cytokines in elderly patients with acute cerebral hemorrhage and its clinical significance. Methods Sixty elderly patients with acute cerebral hemorrhage admitted from the Eighth People’s Hospital of Dongguan City from March 2013 to March 2016 were selected as the observation group and another 60 healthy subjects were selected as the control group. The levels of serum inflammatory factors in patients with acute cerebral hemorrhage and those with different severity and prognosis were compared. Results The levels of serum IL-1, IL-6, IL-10, hs-CRP and TNF-α in observation group were significantly higher than those in control group Higher than the control group (P <0.05). The levels of IL-1, IL-6, IL-10, hs-CRP and TNF-α in patients with severe acute intracerebral hemorrhage were significantly higher than those in patients with mild or moderate acute cerebral hemorrhage. -6, IL-10, hs-CRP and TNF-α in patients with mild acute cerebral hemorrhage (P <0.05). The serum levels of IL-1, IL-6, IL-10, hs-CRP and TNF-α in patients with death were higher than those in survivors (P <0.05). Conclusion Serum levels of inflammatory cytokines are elevated in elderly patients with acute cerebral hemorrhage and are related to the severity and prognosis of the patients.