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目的：研究胶原蛋白的性质及聚甲基丙烯酸羟乙酯［ｐｏｌｙ（ＨＥＭＡ）］－Ⅲ型胶原烧伤贴膜的制备方法。方法：从小牛皮中提取Ⅲ型胶原蛋白，与ｐｏｌｙ（ＨＥＭＡ）、乙二醇混合，用过硫酸铵和偏亚硫酸钠引发交联反应，制成烧伤用贴膜；在膜中加入药物吲哚美辛，并做体外溶出实验。结果：ｐｏｌｙ（ＨＥＭＡ）－Ⅲ型胶原贴膜具有良好的弹性、柔软性、吸湿性和粘附性；吲哚美辛的体外累积释放百分量－时间曲线表明，其多孔的海绵状结构是良好的药物释放系统。结论：ｐｏｌｙ（ＨＥＭＡ）－Ⅲ型胶原的复合物是制备烧伤用创面敷料的良好材料。
Objective: To study the properties of collagen and preparation of poly (HEMA) - Ⅲ collagen burns film. Methods: Collagen Ⅲ was extracted from calf leather, mixed with poly (HEMA) and ethylene glycol, and cross-linked with ammonium persulfate and sodium metabisulfite to form a burn film. The drug indomethacin, And in vitro dissolution experiments. Results: The poly (HEMA) -Ⅲcollagen film had good elasticity, softness, hygroscopicity and adhesiveness. The cumulative release percentage of indometacin in vitro showed that the porous sponge-like structure was good Drug delivery system. Conclusion: The poly (HEMA) -Ⅲ collagen complex is a good material for the preparation of wound dressing for burn wounds.