精氨酸加压素(arginine vasopressin,AVP)是世界上发现最早的神经内分泌激素之一,也常简称加压素。以往的研究表明加压素在下丘脑合成后通过垂体后叶释放入血,循外周血发挥广泛的生理调节作用,如参与水盐代谢,心血管功能的调节。但除此以外,近年来的研究表明,该神经内分泌激素及其受体也在中枢神经系统内也有广泛的分布,并且发挥重要的生物学作用。本文就近年来该激素在疼痛和社会行为等方面的研究进展进行综述。 Arginine vasopressin (AVP) is one of the earliest neuroendocrine hormones found in the world, often referred to as vasopressin. Previous studies have shown that vasopressin is released into the bloodstream through the posterior pituitary after synthesis in the hypothalamus, allowing peripheral blood to exert a wide range of physiological effects, such as participation in the regulation of water and salt metabolism and cardiovascular function. In addition, however, recent studies have shown that the neuroendocrine hormones and their receptors are also widely distributed in the central nervous system and play an important biological role. This review summarizes the progress of this hormone in pain and social behavior in recent years.