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47名复发性晚期上皮性卵巢癌病人为治疗对象;他们在此之前至少已接受过一种含顺铂或卡铂的方案治疗,但无效。 治疗方法:紫杉醇250mg/m~2溶于5％葡萄糖液中持续24小时静脉灌注;注药期间及注完药后6小时内观察、监护。每隔21天重复疗程。注完紫杉醇后24小时开始应用G-CSF,皮下注射,每天10μg/kg,直至粒细胞绝对数>1.5×10~9/L,连续保持两天,或白细胞总数>30×10~9/L。 因为紫杉醇和/或其乳化EL-乙醇载色剂可能引起超敏反应和心律失常,因此凡证明有Ⅱ或Ⅲ度心脏阻滞者,以后各疗程均在监护病
47 patients with recurrent advanced epithelial ovarian cancer were treated; they had previously received at least one regimen containing cisplatin or carboplatin, but were ineffective. Treatment: paclitaxel 250mg / m ~ 2 dissolved in 5% glucose solution for 24 hours intravenous infusion; injection and injection within 6 hours after observation, monitoring. Repeat treatment every 21 days. G-CSF was injected 24 hours after the injection of paclitaxel and injected subcutaneously at a dose of 10 μg / kg daily until the absolute number of granulocytes> 1.5 × 10 9 / L for two consecutive days or the total number of white blood cells> 30 × 10 9 / L . Because paclitaxel and / or its emulsified EL-ethanol vehicles may cause hypersensitivity reactions and arrhythmias, so who have proved Ⅱ or Ⅲ degree heart block, after the treatment in the care of the disease