论文部分内容阅读
目的探讨类风湿性关节炎(RA)遗传易感性与FCRL3的单核苷酸多态性的关系。方法采用病例对照法,分别收集RA患者和正常对照各184例,通过连接酶检测反应方法检测FCRL3 rs7522061位点的基因型,分析基因型及等位基因频率在两组中的分布。结果 FCRL3 rs7522061位点的等位基因频率和基因型频率在病例组和对照组中的分布差异无统计学意义(χ2=0.815,P=0.367;χ2=0.865,P=0.649)。结论安徽省汉族RA患者遗传易感性与FCRL3rs7522061位点无关。
Objective To investigate the relationship between genetic susceptibility to rheumatoid arthritis (RA) and single nucleotide polymorphism (SNP) of FCRL3. Methods A total of 184 cases of RA patients and normal controls were collected by case control method. The genotypes of FCRL3 rs7522061 locus were detected by ligase detection reaction method, and the distribution of genotype and allele frequencies in both groups were analyzed. Results There was no significant difference in allele frequency and genotype frequency between FCRL3 rs7522061 locus and control group (χ2 = 0.815, P = 0.367; χ2 = 0.865, P = 0.649). Conclusion The genetic susceptibility of RA patients in Han nationality in Anhui province has nothing to do with the location of FCRL3 rs7522061.