子痫前期(pre-eclampsia,PE)是妊娠期严重并发症,与母体及围产儿不良结局的发生有密切关系,是孕产妇严重并发症发生的主要原因~([1]),同时该疾病伴有较高的围产儿发病率及死亡率,其中围产儿死亡率约为10%,早产发生率约为15%,胎儿生长受限(FGR)发生率约为50%~([2])。根据发 Pre-eclampsia (PE), a serious complication of pregnancy, is closely related to maternal and perinatal adverse outcomes and is a major cause of severe maternal complications. [1] With a high perinatal morbidity and mortality, of which perinatal mortality is about 10%, premature birth is about 15%, fetal growth restriction (FGR) is about 50% ~ ([2]) . According to the hair