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目的研制塞来昔布脂质体凝胶,并对其体外经皮渗透动力学进行考察。方法采用薄膜分散法制备塞来昔布脂质体,均匀设计筛选最佳处方及制备工艺,并以卡波姆940为基质制成脂质体凝胶;用Franz扩散池研究塞来昔布脂质体凝胶与塞来昔布普通凝胶的经皮渗透规律。结果塞来昔布脂质体凝胶的平均粒径为(369.5±10.8)nm,平均包封率为(81.6±2.2)%(n=3);体外透皮试验表明塞来昔布脂质体凝胶的累积透过量显著大于普通凝胶(P<0.05),药物透皮速率与皮肤蓄积量显著大于普通凝胶(P<0.01)。结论塞来昔布脂质体凝胶制备简单,能促进药物透皮吸收,值得进一步研究。
Objective To develop celecoxib liposome gel and investigate its percutaneous dermal penetration kinetics. Methods Celecoxib liposomes were prepared by thin-film dispersion method, and the best prescriptions and preparation techniques were designed and prepared uniformly. Liposome gel was prepared by using Carbomer 940 as matrix. The effects of celecoxib Transdermal permeation of plastid gel and celecoxib gel. Results The average particle size of celecoxib gel was (369.5 ± 10.8) nm and the average entrapment efficiency was (81.6 ± 2.2)% (n = 3). The in vitro transdermal test showed that celecoxib lipids The cumulative permeation volume of somatic gel was significantly greater than that of normal gel (P <0.05), and the drug transdermal rate and skin volume were significantly larger than that of normal gel (P <0.01). Conclusion Celecoxib liposome gel preparation is simple, can promote drug transdermal absorption, worthy of further study.