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本研究探讨了SAC及rIL－2对CVIDB细胞的影响、选择性IgA缺陷患儿Ig分泌细胞功能及若干PIDIg分泌细胞功能及其与血清Ig水平的相关性。结果提示：（1）通过SAC及rIL－2对CVIDB细胞的影响，阐明了CVIDB细胞的异质性和复杂性。为区别对待B细胞分化不同阶段发生障碍提供了理论基础。（2）在对其他类型PID研究中我们证明，Ig分泌细胞数与血清Ig水平呈平衡关系。（3）我们首次建立了以测定未培养PBMCs中的Ig分泌细胞对免疫缺陷及健康人的体内Ig生成能力进行评价的新方法。
This study investigated the effects of SAC and rIL-2 on CVIDB cells, the function of Ig secreting cells and the function of several PIDIg-secreting cells in children with selective IgA deficiency and their relationship with serum Ig levels. The results suggest that: (1) The CVIDB cells’ influence on SAC and rIL-2 clarifies the heterogeneity and complexity of CVIDB cells. Which provides a theoretical basis for distinguishing the different stages of B cell differentiation from occurring. (2) In other types of PID studies we demonstrated that the number of Ig-secreting cells is in a balanced relationship with serum Ig levels. (3) For the first time, we established a novel method for the evaluation of Ig-producing capacity in immunodeficient and healthy human by measuring Ig-secreting cells in uncultured PBMCs.