乙胺碘呋酮(Amiodarone)是一种同甲状腺素化学结构相似的苯丙呋喃衍化物。开始用以治疗心绞痛,以后电生理学研究表明,该药增加心肌的绝对不应期,延长心房肌和心室肌的动作电位时程而不改变静息膜电位,实际上延迟了复极化并延长了 Q—T间期,故近10年来用于抗心律失常。大剂量应用可抑制心脏的传导系统,尤其是窦房结,并有轻微的负性肌力作用。该药能扩张冠状动脉及周围血管、减慢心率,从而降低氧耗 Amiodarone is a benzofuran derivative that has a similar chemical structure to thyroxine. Began to treat angina pectoris, later electrophysiological studies have shown that the drug increases the absolute refractory period of the myocardium, prolonging the action potential duration of atrial and ventricular muscles without changing the resting membrane potential, actually delaying the repolarization and prolonging The Q-T interval, so the past 10 years for anti-arrhythmia. High-dose applications can inhibit the heart’s conduction system, especially the sinus node, and a slight negative inotropic effect. The drug can expand the coronary arteries and peripheral blood vessels, slow down the heart rate, thereby reducing oxygen consumption