环氧化酶是合成各种前列腺素的关键酶,参与了机体许多生理和病理过程。其具有两种亚型,其中环氧化酶-2(COX-2)是其诱导型,在正常生理状态下很少表达,但在多种恶性肿瘤中呈高度表达。已知COX-2主要通过影响细胞的生长增殖与分化,抑制细胞凋亡及促进肿瘤血管生成等一系列机制发挥促癌作用,而COX-2的选择性抑制剂能减少肿瘤的增生、迁移和生长。本文就COX-2及其抑制剂与脑胶质瘤的关系作简要综述。 Cyclooxygenase is a key enzyme in the synthesis of various prostaglandins and participates in many physiological and pathological processes in the body. It has two subtypes, of which cyclooxygenase-2 (COX-2) is inducible, rarely expressed under normal physiological conditions, but highly expressed in a variety of malignancies. COX-2 is known to play a role in promoting cancer through a series of mechanisms such as affecting proliferation and differentiation of cells, inhibiting apoptosis and promoting tumor angiogenesis. However, selective inhibitors of COX-2 can reduce tumor proliferation, migration and Grow. This article briefly reviews the relationship between COX-2 and its inhibitors and gliomas.