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铁蛋白是体内铁的储存形式,一般情况下血清铁蛋白(SF)含量反映体内铁的储备量。但在一些恶性病变,如肺癌、肝癌、乳腺癌等疾患时,常见SF明显升高而不伴随铁储备增加,虽然此时SF升高的原因尚未完全揭晓,但SF含量与肿瘤诊断及预后的关系引起诸多学者的兴趣,近十多年来多有报道,唯结果不一,诊断价值尚在争议之中。一、对象与方法本文用酶联免疫吸附法分别对53例肺癌病人(男41冽,女12例,年龄32～70岁),14例肺部良性疾患者作了血清SF测定,并以22例健康男性(25～40岁)作正常对照,来研究SF对肺癌的诊断价值。又以双夹心法对部分病例作了癌组织中铁蛋白的免疫定位,以期探讨肺癌患者SF升高与癌组织合
Ferritin is a stored form of iron in the body. In general, serum ferritin (SF) content reflects the amount of iron in the body. However, in some malignant diseases, such as lung cancer, liver cancer, breast cancer and other diseases, the common SF increased significantly without an increase in iron reserves, although at this time the cause of SF elevation has not been fully revealed, but the SF content and tumor diagnosis and prognosis The relationship has attracted the interest of many scholars and has been reported for more than a decade. The only result is that the diagnostic value is still in dispute. I. Object and method Serum SF was measured in 53 patients with lung cancer (41 males and 12 females, aged 32-70 years) and 14 patients with benign pulmonary disease by enzyme-linked immunosorbent assay (ELISA). Healthy men (25-40 years old) were used as normal controls to study the diagnostic value of SF in lung cancer. In addition, the ferritin immunolocalization in cancer tissue was performed in some cases with a double-sandwich method in order to explore the combination of elevated SF and cancerous tissue in patients with lung cancer.