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坏疽性脓皮病(pyoderma gangrenosum,简称PG)是具有独特的临床特征的破坏性炎性皮肤病.因为没有特异性的组织病理学或实验室的异常,所以诊断完全依靠临床.自从Brunsting等(1930)首次报告以来,PG合并系统性疾患的报告增加了.近年来曾报告此病有体液与细胞免疫的异常以及多形核嗜中性白细胞功能的紊乱.尽管有各种各样的临床合并症以及研究发现,但此病的发病机制仍然不明,因而没有合理的治疗方法,本文目的是复习近来有关本病临床和研究的资料,并总结目前对本病的处理.PG合并系统性疾病
Pyoderma gangrenosum (PG) is a devastating inflammatory skin disease with unique clinical features that rely entirely on clinical diagnosis because there is no specific histopathology or laboratory abnormality Since Brunsting et al ( 1930) Since the first report, there has been an increase in reports of PG-associated systemic disorders, which have been reported in recent years as abnormalities of humoral and cellular immunity and disorders of polymorphonuclear neutrophil function. Despite various clinical combinations Disease and the study found that the pathogenesis of the disease is still unknown and therefore there is no reasonable treatment, the purpose of this paper is to review the recent clinical data on the disease and research, and summarize the current treatment of the disease.GPS combined with systemic diseases