Synthesis, Crystal Structure and Biological Activity of 2-((2,2-Dimethyl-2,3-dihydrobenzofuran-7-yl)

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The title compound 2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-(3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-yl) acetamide(C25H23N3O4, Mr = 429.46) has been synthesized, and its structure was characterized by 1H-NMR, 13C-NMR, H RMS, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/c with a = 20.6205(18), b = 5.2930(5), c = 18.9282(17) ?, β = 94.089(2)°, V = 2060.6(3) ?3, Z = 4, Dc = 1.384 g/cm~3, μ(Mo Ka) = 0.71073 mm~(-1), F(000) = 904, R = 0.0345 and w R = 0.0930. The intramolecular hydrogen bond at N(1)–H(1)···O(2), intermolecular weak interactions at O(3)···H(4) and weak π-π interactions connected the molecules to lead to one-dimensional tapes. Bioassay results indicated that the title compound had moderate herbicidal and fungicidal activities. The title compound 2 - (2,2-dimethyl-2,3-dihydrobenzofuran-7-yl) oxy) -N- (3- (furan-2-yl) -1 -phenyl-1H-pyrazol-5-yl The structure of the acetamide (C25H23N3O4, Mr = 429.46) has been synthesized, and its structure was characterized by 1H-NMR, 13C-NMR, H RMS, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21 / c with a = 20.6205 (18), b = 5.2930 (5), c = 18.9282 (17) ?,? = 94.089 (2) °, V = 2060.6 (3)? 3, Z = 4, Dc = 1.384 g / cm ~ 3, Mo Ka = 0.71073 mm -1, F 000 = 904, R = 0.0345 and w R = 0.0930. The intramolecular hydrogen bond at N (1) -H Bioassay results indicated that the title compound had moderate herbicidal and (2) intermolecular weak interactions at O ​​(3) ··· H (4) and weak π-π interactions connected the molecules to lead to one- fungicidal activities.
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